The psychometric properties of the amharic version of EuroQoL five-dimensions-five level among Ethiopian cervical cancer patients

• Published in: Health and quality of life outcomes 2024-11, Vol.22 (1), p.98-11, Article 98
• Main Authors: Gebremariam, Girma Tekle, Gebretekle, Gebremedhin Beedemariam, Tigneh, Wondemagegnhu, Gashawbeza, Biruck, Belayneh, Alemu, Mengesha, Abdu, Welie, Abraham G, Ali, Eskinder Eshetu
• Format: Article
• Language: English
• Subjects: Adult; Cancer; Cancer patients; Care and treatment; Cervical cancer; Diagnosis; EQ-5D; Ethiopia; Evaluation; Female; Health aspects; HRQoL; Humans; Longitudinal Studies; Middle Aged; Patient outcomes; Psychometric properties; Psychometrics - standards; Quality of life; Quality of Life - psychology; Questionnaires; Reproducibility of Results; Surveys; Surveys and Questionnaires - standards; Uterine Cervical Neoplasms - psychology; Uterine Cervical Neoplasms - therapy
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-024-02305-3

Despite being a widely used generic measure of health-related quality of life worldwide, there is limited evidence on the psychometric properties of the EuroQoL Five-dimensions five level (EQ-5D) among cervical cancer patients in Ethiopia. To evaluate psychometric properties of the Amharic version of EQ-5D among Ethiopian cervical cancer patients. A longitudinal survey of cervical cancer patients receiving treatment at two Ethiopian tertiary care facilities was conducted from March 2022 to July 2023. Participants completed the EQ-5D and the European Organization for Research and Therapy of Cancer (EORTC QLQ-C30) at baseline and after three months on treatment. Effect size and standardized response mean were used to assess responsiveness. Anchor-based and distribution-based methods were used to calculate the minimal clinically important difference (MCID). Minimal detectable change (MDC) ratios were computed at the individual and group levels. Statistical significance was determined at p  0.6) and the instrument showed good discriminate validity between patients with different health states. The effect size ranged between - 0.12 and 0.60 for the EQ-5D index value and - 0.12 to 1.16 for the EQ VAS, indicating small to large responsiveness. The average (range) MCID value of the EQ-5D index was 0.10-0.15. The findings showed that MCID to MDC ratios at the group level were more clinically meaningful than the individual level. The EQ-5D effectively detected changes and discriminate patients with different levels of health. While group-level MCIDs were established in this study, further studies are recommended to prove its usefulness at the individual-level.