Antimicrobial, Antioxidant, and Wound Healing Properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC

Microbial infections of various types of wounds are a challenge to the treatment of wounds and wound healing. The study was to investigate antimicrobial and antioxidant properties of methanol leaf and stem bark extracts of Kigelia africana and methanol leaf and root extracts of Strophanthus hispidus...

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Bibliographic Details
Published in:Advances in Pharmacological Sciences 2013-01, Vol.2013 (2013), p.133-142
Main Authors: Adarkwa-Yiadom, Martin, Mensah, Kwesi Boadu, Boakye, Yaw Duah, Agyepong, Nicholas, Dwobeng, Anita Serwaa, Agyare, Christian, Ayande, Patrick George
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Botanical research
Free radicals
Health aspects
Infections
Lamiales
Materia medica, Vegetable
Microorganisms
Pharmaceutical sciences
Pharmacology
Phytochemicals
Phytochemistry
Plant extracts
Skin
Syphilis
Ulcers
Wound healing
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Summary:Microbial infections of various types of wounds are a challenge to the treatment of wounds and wound healing. The study was to investigate antimicrobial and antioxidant properties of methanol leaf and stem bark extracts of Kigelia africana and methanol leaf and root extracts of Strophanthus hispidus and also to determine wound healing properties of the extracts. The antimicrobial activities of the methanol extracts were determined against two Gram-positive and two Gram-negative bacteria and a fungus using agar diffusion and micro-dilution methods. The antioxidant activity was determined using 1,1-diphenyl-2-picryl–hydrazyl (DPPH) method. The influence of the extracts on rate of wound closure was investigated using the excision wound model and histopathological investigation of treated and untreated wound tissues performed. The MICs of leaf extract of K. africana against test organisms were 2.5–7.5 mg/mL and stem bark extract were 2.25–7.5 mg/mL. The leaf extract of S. hispidus had MIC range of 2.5–7.5 mg/mL and 2.5–10 mg/mL for root extract. The IC50 of leaf and stem bark extracts of K. africana were 56.9 and 13.7 μg/mL, respectively and leaf and root of S. hispidus were 49.8 and 45.1 μg/mL, respectively. K. africana extracts (7.5% w/w) showed significant (P
ISSN:1687-6334
2633-4682
2633-4690
1687-6342
DOI:10.1155/2013/692613