Metagenomic analysis examines oral microbiome changes and interplay with immune response following prenatal total oral rehabilitation

Suboptimal maternal oral health during pregnancy is potentially associated with adverse birth outcomes and increased dental caries risks in children. This study aimed to assess the oral microbiome and immune response following an innovative clinical regimen, Prenatal Total Oral Rehabilitation (PTOR)...

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Bibliographic Details
Published in:Journal of translational medicine 2023-03, Vol.21 (1), p.172-172, Article 172
Main Authors: Wu, Tong Tong, Sohn, Michael, Manning, Samantha, Beblavy, Robert, Gill, Steven, Quataert, Sally, Vasani, Shruti, Jang, Hoonji, Zeng, Yan, Bruno, Jennifer, Vazquez, Adriana, Fiscella, Kevin, Xiao, Jin
Format: Article
Language:English
Subjects:
Bacteriome
Birth
Care and treatment
Chemokines
Child
Children & youth
Clinical trials
Cytokines
Dental Caries
Disease
Family
Female
Genomes
Gestational age
Health aspects
Humans
Immune markers
Immune response
Infant, Newborn
Influence
Metagenomics
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Monocyte chemoattractant protein 1
Mothers
Mycobiome
Oral health
Oral hygiene
Pathogens
Physical Therapy Modalities
Pre-eclampsia
Preeclampsia
Pregnancy
Pregnancy complications
Pregnant women
Prenatal oral health care
Prospective Studies
Rehabilitation
Teeth
Womens health
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Summary:Suboptimal maternal oral health during pregnancy is potentially associated with adverse birth outcomes and increased dental caries risks in children. This study aimed to assess the oral microbiome and immune response following an innovative clinical regimen, Prenatal Total Oral Rehabilitation (PTOR), that fully restores women's oral health to a "disease-free status" before delivery. This prospective cohort study assessed 15 pregnant women at baseline and 3 follow-up visits (1 week, 2 weeks, and 2 months) after receiving PTOR. The salivary and supragingival plaque microbiomes were analyzed using metagenomic sequencing. Multiplexed Luminex cytokine assays were performed to examine immune response following PTOR. The association between salivary immune markers and oral microbiome was further examined. PTOR was associated with a reduction of periodontal pathogens in plaque, for instance, a lower relative abundance of Tannerella forsythia and Treponema denticola at 2 weeks compared to the baseline (p 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-023-03997-9