Polyethylene Glycol Cross-Linked Hydrogel for Drug Absorption Properties

• Published in: Journal of pharmacy & bioallied science 2024-04, Vol.16 (Suppl 2), p.S1201-S1203
• Main Authors: Durairaj, Vta, Kalpana, R, Kumar, Vinay
• Format: Article
• Language: English
• Subjects: Biocompatibility; characterization; Chemical properties; Crosslinked polymers; Cytotoxicity; Glutaraldehyde; human and well being; hydrogel; Hydrogels; life on land; Original; pegda; Polyethylene glycol; Water content
• ISSN: 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.jpbs_540_23

Three-dimensional polymeric networks called hydrogels have drawn a lot of interest in a variety of biomedical applications because of their distinctive qualities, like high water content and biocompatibility. Hydrogels can be strengthened mechanically and become more stable via cross-linking. In this study, we described the synthesis and characterization of a cross-linked hydrogel made of polyethylene glycol (PEG) capable of absorbing drug. The hydrogel was created by using a polymerization procedure to cross-link PEG chains. In order to allay this worry, we added particular functional groups to the hydrogel matrix that had a strong affinity for glutaraldehyde. These functional groups made it easier for excess glutaraldehyde to be absorbed and sequestered inside the hydrogel, lowering its cytotoxic potential. After incubation with the hydrogel, the residual glutaraldehyde concentration in solution was measured in order to assess the glutaraldehyde absorption potential.