Genetic Susceptibility of the Host in Virus-Induced Diabetes

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be co...

Full description

Saved in:
Bibliographic Details
Published in:Microorganisms (Basel) 2020-07, Vol.8 (8), p.1133
Main Authors: Mine, Keiichiro, Yoshikai, Yasunobu, Takahashi, Hirokazu, Mori, Hitoe, Anzai, Keizo, Nagafuchi, Seiho
Format: Article
Language:English
Subjects:
Animal models
Autoimmune diseases
Autoimmunity
Cytokines
Diabetes
Diabetes mellitus (insulin dependent)
Enteroviruses
Environmental factors
Fibroblasts
Gene expression
Genetic aspects
Genetic factors
Genetic susceptibility
Gestational diabetes
Host-virus relationships
Infections
Insulin resistance
Kinases
Mutation
Pathogenesis
Phosphorylation
Polymorphism
Proteins
Review
Risk factors
Studies
susceptibility genes
Viral infections
virus
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms8081133