In Vivo Assessment and Monitoring of Burn Wounds Using a Handheld Terahertz Hyperspectral Scanner

The accuracy of clinical assessment techniques in diagnosing partial‐thickness burn injuries has remained as low as 50–76%. Depending on the burn depth and environmental factors in the wound, such as reactive oxygen species, inflammation, and autophagy, partial‐thickness burns can heal spontaneously...

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Bibliographic Details
Published in:Advanced photonics research 2022-05, Vol.3 (5), p.n/a
Main Authors: Osman, Omar B., Harris, Zachery B., Zhou, Juin W., Khani, Mahmoud E., Singer, Adam J., Arbab, M. Hassan
Format: Article
Language:English
Subjects:
Accuracy
burn imaging
Burns
Electrons
handheld THz-TDS scanner
histology
Injuries
partial-thickness burn characterization
Radiation
Scanners
skin tissue hyperspectral imaging
Spectrum analysis
terahertz time-domain spectroscopy
Wound healing
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Summary:The accuracy of clinical assessment techniques in diagnosing partial‐thickness burn injuries has remained as low as 50–76%. Depending on the burn depth and environmental factors in the wound, such as reactive oxygen species, inflammation, and autophagy, partial‐thickness burns can heal spontaneously or require surgical intervention. Herein, it is demonstrated that terahertz time‐domain spectral imaging (THz‐TDSI) is a promising tool for in vivo quantitative assessment and monitoring of partial‐thickness burn injuries in large animals. We used a novel handheld THz‐TDSI scanner to characterize burn injuries in a porcine scald model with histopathological controls. Statistical analysis (n = 40) indicates that the THz‐TDSI modality can accurately differentiate between partial‐thickness and full‐thickness burn injuries (1‐way ANOVA, p 
ISSN:2699-9293
2699-9293
DOI:10.1002/adpr.202100095