Steroid Hormone Receptors: Links With Cell Cycle Machinery and Breast Cancer Progression

Progression of cells through cell cycle consists of a series of events orchestrated in a regulated fashion. Such processes are influenced by cell cycle regulated expression of various proteins where multiple families of transcription factors take integral parts. Among these, the steroid hormone rece...

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Bibliographic Details
Published in:Frontiers in oncology 2021-03, Vol.11, p.620214-620214
Main Authors: Saha, Suryendu, Dey, Samya, Nath, Somsubhra
Format: Article
Language:English
Subjects:
androgen receptor (AR)
breast cancer
cell cycle
estrogen receptor (ER)
Oncology
progesterone receptor (PR)
steroid hormone receptors (SHRs)
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Summary:Progression of cells through cell cycle consists of a series of events orchestrated in a regulated fashion. Such processes are influenced by cell cycle regulated expression of various proteins where multiple families of transcription factors take integral parts. Among these, the steroid hormone receptors (SHRs) represent a connection between the external hormone milieu and genes that control cellular proliferation. Therefore, understanding the molecular connection between the transcriptional role of steroid hormone receptors and cell cycle deserves importance in dissecting cellular proliferation in normal as well as malignant conditions. Deregulation of cell cycle promotes malignancies of various origins, including breast cancer. Indeed, SHR members play crucial role in breast cancer progression as well as management. This review focuses on SHR-driven cell cycle regulation and moving forward, attempts to discuss the role of SHR-driven crosstalk between cell cycle anomalies and breast cancer.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.620214