Capsaicin Inhibits Inflammation and Gastric Damage during H pylori Infection by Targeting NF-kB–miRNA Axis

Helicobacter pylori (H. pylori) infection is considered as one of the strongest risk factors for gastric disorders. Infection triggers several host pathways to elicit inflammation, which further proceeds towards gastric complications. The NF-kB pathway plays a central role in the upregulation of the...

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Bibliographic Details
Published in:Pathogens (Basel) 2022-06, Vol.11 (6), p.641
Main Authors: Saha, Kalyani, Sarkar, Deotima, Khan, Uzma, Karmakar, Bipul Chandra, Paul, Sangita, Mukhopadhyay, Asish K., Dutta, Shanta, Bhattacharya, Sushmita
Format: Article
Language:English
Subjects:
AKT protein
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial activity
Binding sites
Capsaicin
Cytokines
Damage
E-cadherin
Gastric cancer
Gene expression
Genes
H. pylori
Helicobacter pylori
Infections
Inflammation
miRNA
NF-kB
NF-κB protein
Pathogenesis
Phosphorylation
Risk analysis
Risk factors
Transcription factors
Virulence
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Summary:Helicobacter pylori (H. pylori) infection is considered as one of the strongest risk factors for gastric disorders. Infection triggers several host pathways to elicit inflammation, which further proceeds towards gastric complications. The NF-kB pathway plays a central role in the upregulation of the pro-inflammatory cytokines during infection. It also regulates the transcriptional network of several inflammatory cytokine genes. Hence, targeting NF-kB could be an important strategy to reduce pathogenesis. Moreover, treatment of H. pylori needs attention as current therapeutics lack efficacy due to antibiotic resistance, highlighting the need for alternative therapeutic approaches. In this study, we investigated the effects of capsaicin, a known NF-kB inhibitor in reducing inflammation and gastric complications during H. pylori infection. We observed that capsaicin reduced NF-kB activation and upregulation of cytokine genes in an in vivo mice model. Moreover, it affected NF-kB–miRNA interplay to repress inflammation and gastric damages. Capsaicin reduced the expression level of mir21 and mir223 along with the pro-inflammatory cytokines. The repression of miRNA further affected downstream targets such as e-cadherin and Akt. Our data represent the first evidence that treatment with capsaicin inhibits inflammation and induces antimicrobial activity during H. pylori infection. This alternative approach might open a new avenue in treating H. pylori infection, thus reducing gastric problems.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11060641