Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling

Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental program. Embryonic and adult angiogenesis in the brain is governed by the coordinated activity of endothelial progenitor cells, brain microvascular...

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Bibliographic Details
Published in:Frontiers in physiology 2016-12, Vol.7, p.599-599
Main Authors: Malinovskaya, Natalia A, Komleva, Yulia K, Salmin, Vladimir V, Morgun, Andrey V, Shuvaev, Anton N, Panina, Yulia A, Boitsova, Elizaveta B, Salmina, Alla B
Format: Article
Language:English
Subjects:
Angiogenesis
Blood-brain barrier (BBB)
endothelial progenitor cells
neurovascular unit
Nicotinamide adenine dinucleotide (NAD+)
Physiology
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Summary:Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental program. Embryonic and adult angiogenesis in the brain is governed by the coordinated activity of endothelial progenitor cells, brain microvascular endothelial cells, and non-endothelial cells contributing to the establishment of the BBB (pericytes, astrocytes, neurons). Metabolic and functional plasticity of endothelial progenitor cells controls their timely recruitment, precise homing to the brain microvessels, and efficient support of brain angiogenesis. Deciphering endothelial progenitor cells physiology would provide novel engineering approaches to establish adequate microfluidically-supported BBB models and brain microphysiological systems for translational studies.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2016.00599