Tacrolimus Induced Diabetic Ketoacidosis Following Allogeneic Stem Cell Transplantation

Higher incidence of diabetes has been reported following hematopoietic stem cell transplantation (HSCT) and solid organ transplantation with rare occurrence of diabetic ketoacidosis (DKA). DKA in a post allogeneic stem cell transplant patient following the use of tacrolimus has not been reported. We...

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Bibliographic Details
Published in:Mediterranean journal of hematology and infectious diseases 2014-08, Vol.1
Main Authors: Sanjeev Kumar Sharma, Arpita Arora, Nitin Gupta, Mayank Dhamija, Punita Pavecha, Sweta Kothari, Vipin Khandelwal, Dharma Choudhary
Format: Article
Language:English
Subjects:
bone marrow transplant
GVHD
Hematology
Tacrolimus
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Summary:Higher incidence of diabetes has been reported following hematopoietic stem cell transplantation (HSCT) and solid organ transplantation with rare occurrence of diabetic ketoacidosis (DKA). DKA in a post allogeneic stem cell transplant patient following the use of tacrolimus has not been reported. We report here two cases of thalassemia major post allogeneic HCST with liver graft versus host disease (GVHD) who developed DKA while on treatment with tacrolimus. The drug was stopped and patients were treated with intravenous fluids and insulin resulting in complete recovery of DKA.
ISSN:2035-3006