Hyaluronic acid-coated Bi:Cu2O: an H2S-responsive agent for colon cancer with targeted delivery and enhanced photothermal performance

Endogenous hydrogen sulfide (H.sub.2S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors and excellent photothermal performance remains challenging. We prepared hyaluronic...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2022-07, Vol.20 (1), p.1-346, Article 346
Main Authors: Cheng, Yuying, Bo, Haiji, Qin, Ruomeng, Chen, Fulai, Xue, Fengfeng, An, Lu, Huang, Gang, Tian, Qiwei
Format: Article
Language:English
Subjects:
Biocompatibility
Bismuth
Cancer
Care and treatment
Colon
Colon cancer
Colorectal cancer
Computed tomography
Copper oxide
Copper oxides
CT imaging
Cu2O
Cuprite
Dosage and administration
Drug targeting
Endogenous hydrogen sulfide
Evaluation
Hyaluronic acid
Hydrogen sulfide
Lasers
Medical imaging
Methods
Morphology
Nanomaterials
Nanoparticles
Oncology, Experimental
Photothermal therapy
Scanning electron microscopy
Surfactants
Testing
Tumor cells
Tumors
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Summary:Endogenous hydrogen sulfide (H.sub.2S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors and excellent photothermal performance remains challenging. We prepared hyaluronic acid (HA)-coated Bi-doped cuprous oxide (Bi:Cu.sub.2O@HA) via a one-pot method. The HA specifically targets colon cancer tumor cells to improve the enrichment of Bi:Cu.sub.2O@HA at tumor sites, while the doped Bi both enhances the photothermal performance of the H.sub.2S-triggered Cu.sub.2O and serves as an agent for tumor imaging. The results in this work demonstrated that the Bi:Cu.sub.2O@HA nanoparticles exhibit good biocompatibility, target colon cancer tumor cells, facilitate computed tomography imaging, and enhanced H.sub.2S-responsive photothermal therapy performance, resulting in an excellent therapeutic effect in colon cancer. The novel Bi:Cu.sub.2O@HA nanoparticles exhibit excellent tumor targeting and photothermal therapeutic effects, which provide new strategies and insights for colon cancer therapy.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-022-01555-x