N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imid-azol-2-yl)benzeneamine

N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)benzeneamine was obtained by condensation of N-(4-bromobenzyl)-3,1-benzoxazine-2,4-dione (N-(4-bromobenzyl)isatoic anhydride) with 4,5-dimethyl-1,2-phenylenediamine in refluxing acetic acid. This is a rare example of condensation of N-substi...

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Bibliographic Details
Published in:MolBank 2018-03, Vol.2018 (1), p.M979
Main Authors: Dziełak, Monika, Trzybiński, Damian, Czerwińska, Jolanta, Majchrzak, Bartosz, Tudek, Barbara, Woźniak, Krzysztof, Mieczkowski, Adam
Format: Article
Language:English
Subjects:
1,2-phenylenediamine
3,1-benzoxazine-2,4-dione
Acetic acid
Acids
Anhydrides
Benzoxazines
Chemistry
Chromatography
Condensates
crystallographic studies
Crystallography
cytotoxicity
Hydrogen bonds
Investigations
isatoic anhydride
Phenylenediamine
Refluxing
substituted benzimidazoles
Toxicity
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Summary:N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)benzeneamine was obtained by condensation of N-(4-bromobenzyl)-3,1-benzoxazine-2,4-dione (N-(4-bromobenzyl)isatoic anhydride) with 4,5-dimethyl-1,2-phenylenediamine in refluxing acetic acid. This is a rare example of condensation of N-substituted 3,1-benzoxazine-2,4-dione with 1,2-phenylenediamine, which resulted in the formation of a benzimidazole derivative with a moderate yield. Crystallographic studies and initial biological screening were performed for the obtained product.
ISSN:1422-8599
1422-8599
DOI:10.3390/M979