A Carabrane-Type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis

Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpeno...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18), p.5841
Main Authors: Zheng, Yi-Dan, Zhang, Ying, Ma, Jun-Yi, Sang, Chun-Yan, Yang, Jun-Li
Format: Article
Language:English
Subjects:
Asteraceae - chemistry
Bioinformatics
Biosynthesis
Cancer therapies
Carpesium cernuum L
Cell Line, Tumor
Cell Proliferation
Cytotoxicity
Ferroptosis
Humans
Mass spectrometry
Mass spectroscopy
Metabolism
Morphology
natural product
Pancreas - metabolism
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - pathology
Peptides
Pharmacology
Proteins
Proteomics
Signal transduction
Steroids
SW1990 cells
Tumorigenesis
Tumors
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Summary:Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibition and anti-migration and anti-invasion activity against SW1990 cells. Furthermore, the tandem mass spectrometry and network pharmacology analysis showed that this activity may be related to the ferroptosis and Hippo signaling pathway. Taken together, our results demonstrated that carabrone exhibited prominent anti-pancreatic cancer activity and could be a promising agent against pancreatic cancer.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27185841