Phenolic compounds of Iris adriatica and their antimycobacterial effects

Little is known about the pharmacological activities of (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using mc 155. One obtained fraction was found t...

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Bibliographic Details
Published in:Acta pharmaceutica (Zagreb, Croatia) Croatia), 2019-12, Vol.69 (4), p.673-681
Main Authors: Ochensberger, Sandra, Alperth, Fabian, Mitić, Božena, Kunert, Olaf, Mayer, Stefanie, Mourão, Maria Ferreira, Turek, Ivana, Luca, Simon Vlad, Skalicka-Woźniak, Krystyna, Maleš, Željan, Hruševar, Dario, Duka, Ivan, Bucar, Franz
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Benzophenone
Benzophenones - pharmacology
Bioassays
Endemic plants
Ethidium bromide
Fractionation
iris adriatica
Iris Plant - chemistry
Isoflavones - pharmacology
MIC
Microbial Sensitivity Tests - methods
Minimum inhibitory concentration
mycobacterium smegmatis
Mycobacterium smegmatis - drug effects
Phenolic compounds
Phenols
Phenols - pharmacology
Plant Extracts - pharmacology
Radix Iridis
resistance modulation
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Summary:Little is known about the pharmacological activities of (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using mc 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L . Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.
ISSN:1846-9558
1330-0075
1846-9558
DOI:10.2478/acph-2019-0037