High-sensitivity C-reactive protein could be a potential indicator of bone mineral density in adolescents aged 10–20 years

• Published in: Scientific reports 2022-05, Vol.12 (1), p.7119-7119, Article 7119
• Main Authors: Ye, Weiran, Cheng, Shi, Xiao, Jin, Yu, Hui
• Format: Article
• Language: English
• Subjects: 692/308/53/2423; 692/4023/1670/316/801; 692/4023/1671/63; Adolescent; Adolescents; Adult; Bone Density; Bone mineral density; C-reactive protein; C-Reactive Protein - metabolism; Child; Cross-Sectional Studies; Female; Humanities and Social Sciences; Humans; Linear Models; Male; multidisciplinary; Nutrition Surveys; Population studies; Regression analysis; Science; Science (multidisciplinary); Teenagers; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-11209-5

There was very limited evidence linking high-sensitivity C-reactive protein (HS-CRP) and total bone mineral density (BMD) in adolescents. The aim of this population-based study was to investigate the relationship between HS-CRP and total BMD in adolescents aged 10–20 years. A cross-sectional study was performed in the normal U.S. population from the data of the National Health and Nutrition Examination Survey (NHANES). The correlation between HS-CRP and total BMD was evaluated by using weighted multivariate linear regression models. And further subgroup analysis was conducted. There were 1747 participants in this study, 47.1% were female, 29.4% were white, 19.5% were black, and 22.3% were Mexican–American. In the multi-regression model that after the potential confounders had been adjusted, HS-CRP was negatively associated with total BMD. The negative association was also observed in the subgroup analyses stratified by gender and age. Our results demonstrated that higher HS-CRP was negatively correlated with total BMD in 10–20 years old adolescents.