Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction

Astaxanthin, originating from seafood, is a naturally occurring red carotenoid pigment. Previous studies have focused on its antioxidant properties; however, whether astaxanthin possesses a desired anti-inflammatory characteristic to regulate the dendritic cells (DCs) for sepsis therapy remains unkn...

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Bibliographic Details
Published in:Marine drugs 2021-06, Vol.19 (6), p.346
Main Authors: Yin, Yinyan, Xu, Nuo, Shi, Yi, Zhou, Bangyue, Sun, Dongrui, Ma, Bixia, Xu, Zhengzhong, Yang, Jin, Li, Chunmei
Format: Article
Language:English
Subjects:
Antigens
Antioxidant properties
Antioxidants
Arthritis
Astaxanthin
Carotenoids
CCR7 protein
CD40 antigen
CD80 antigen
CD86 antigen
Cell proliferation
Cytokines
Dendritic cells
Endocytosis
Gram-positive bacteria
Homeostasis
immune dysfunction
Inflammation
Interleukin 10
Interleukin 6
lipopolysaccharide
Lipopolysaccharides
Lymphocytes
Lymphocytes T
Morphology
Mortality
Oral administration
Pathogens
Proliferation
Seafood
Seafoods
Sepsis
Survival
Tumor necrosis factor-α
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Summary:Astaxanthin, originating from seafood, is a naturally occurring red carotenoid pigment. Previous studies have focused on its antioxidant properties; however, whether astaxanthin possesses a desired anti-inflammatory characteristic to regulate the dendritic cells (DCs) for sepsis therapy remains unknown. Here, we explored the effects of astaxanthin on the immune functions of murine DCs. Our results showed that astaxanthin reduced the expressions of LPS-induced inflammatory cytokines (TNF-α, IL-6, and IL-10) and phenotypic markers (MHCII, CD40, CD80, and CD86) by DCs. Moreover, astaxanthin promoted the endocytosis levels in LPS-treated DCs, and hindered the LPS-induced migration of DCs via downregulating CCR7 expression, and then abrogated allogeneic T cell proliferation. Furthermore, we found that astaxanthin inhibited the immune dysfunction of DCs induced by LPS via the activation of the HO-1/Nrf2 axis. Finally, astaxanthin with oral administration remarkably enhanced the survival rate of LPS-challenged mice. These data showed a new approach of astaxanthin for potential sepsis treatment through avoiding the immune dysfunction of DCs.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19060346