Could Vitamins Have a Positive Impact on the Treatment of Parkinson's Disease?

• Published in: Brain sciences 2023-02, Vol.13 (2), p.272
• Main Authors: Sandeep, Sahu, Manas Ranjan, Rani, Linchi, Kharat, Arun S, Mondal, Amal Chandra
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; antioxidant; Antioxidants; Apoptosis; Caffeine; Cohort analysis; Cytokines; Dairy products; Dietary supplements; Dopamine; Dopamine receptors; Flavonoids; Health aspects; Inflammation; Kinases; Lewy bodies; Microbiota; Milk; Movement disorders; MPP; MPTP; Mutation; Neostriatum; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neuroprotection; Nutrient deficiency; Oxidative stress; Paraquat; Parkinson's disease; Pathogenesis; Pathophysiology; Phytochemicals; Probiotics; Proteins; Review; Rotenone; Substantia nigra; Synuclein; Uric acid; Vitamin A; vitamin B; Vitamin D; Vitamins
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci13020272

Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer's disease. Pathophysiologically, it is characterized by intracytoplasmic aggregates of α-synuclein protein in the Lewy body and loss of dopaminergic neurons from substantia nigra pars compacta and striatum regions of the brain. Although the exact mechanism of neurodegeneration is not fully elucidated, it has been reported that environmental toxins such as MPTP, rotenone, paraquat, and MPP induce oxidative stress, which is one of the causative factors for it. To date, there is no complete cure. However, the indispensable role of oxidative stress in mediating PD indicates that antioxidant therapy could be a possible therapeutic strategy against the disease. The deficiency of vitamins has been extensively co-related to PD. Dietary supplementation of vitamins with antioxidant, anti-inflammatory, anti-apoptotic, and free radical scavenging properties could be the potential neuroprotective therapeutic strategy. This review summarizes the studies that evaluated the role of vitamins (A, B, C, D, E, and K) in PD. It will guide future studies in understanding the potential therapeutic role of vitamins in disease pathophysiology and may provide a framework for designing treatment strategies against the disease.