Rates and Determinants of Hospital-Acquired Infection among ICU Patients Undergoing Cardiac Surgery in Developing Countries: Results from EMERGENCY'NGO's Hospital in Sudan

• Published in: Antibiotics (Basel) 2022-09, Vol.11 (9), p.1227
• Main Authors: Spagnolello, Ornella, Fabris, Silvia, Portella, Gina, Raafat Shafig Saber, Dimiana, Giovanella, Elena, Badr Saad, Manahel, Langer, Martin, Ciccozzi, Massimo, d'Ettorre, Gabriella, Ceccarelli, Giancarlo
• Format: Article
• Language: English
• Subjects: Antimicrobial resistance; Cardiac patients; cardiac surgery; Cardiovascular disease; Cardiovascular diseases; Coronary artery disease; Decision making; Developing countries; Drug resistance; Drug resistance in microorganisms; Elective surgery; Emergency medical services; Health aspects; Health services; Heart diseases; Heart surgery; Hospital patients; Hospitals; infection prevalence; Intensive care; intensive care unit; Laboratories; LDCs; Low income groups; Mortality; NGOs; Nongovernmental organizations; Nosocomial infection; Nosocomial infections; Patients; Risk factors; Sudan; Surgery; third-world countries; Variables
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics11091227

Introduction. Knowledge of local and regional antimicrobial resistance (AMR) is crucial in clinical decision-making, especially with critically ill patients. The aim of this study was to investigate the rate and pattern of infections in valvular heart disease patients admitted to the intensive care unit (ICU) at the Salam Centre for Cardiac Surgery in Khartoum, Sudan (run by EMERGENCY NGO). Methods. This is a retrospective, observational study from a single, large international referral centre (part of a Regional Programme), which enrolled patients admitted to the ICU between 1 January and 31 December 2019. Data collected for each patient included demographic data, operating theatre/ICU data and microbiological cultures. Results. Over the study period, 611 patients were enrolled (elective surgery n = 491, urgent surgery n = 34 and urgent medical care n = 86). The infection rate was 14.2% and turned out to be higher in medical than in surgical patients (25.6% vs. 12.4%; p = 0.002; OR = 2.43) and higher in those undergoing urgent surgery than those undergoing elective (29.4% vs. 11.2%; p = 0.004; OR = 3.3). Infection was related to (a) SOFA score (p < 0.001), (b) ICU length of stay (p < 0.001) and (c) days from ICU admission to OT (p = 0.003). A significant relationship between the type of admission (elective, urgent surgery or medical) and the presence of infections was found (p < 0.001). The mortality rate was higher among infected patients (infected vs. infection-free: 10.3% vs. 2.1%; p < 0.001; OR = 5.38; 95% CI: 2.16−13.4; p < 0.001). Conclusions. Hospital-acquired infections remain a relevant preventable cause of mortality in our particular population.