Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies

Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (n=107). FCGR3B CN was determined by three different qPC...

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Bibliographic Details
Published in:Autoimmune Diseases 2013-01, Vol.2013 (2013), p.182-187
Main Authors: Nossent, Johannes C., Becker-Merok, Andrea, Rischmueller, Maureen, Lester, Sue
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Arthritis
Autoantibodies
Clinical medical disciplines: 750
Complications and side effects
Copy number
Copy number variations
Deoxyribonucleic acid
DNA
Enzymes
Fc receptors
Females
Genetic aspects
Genetic research
Genetic susceptibility
Identification and classification
Immune clearance
Immunoassay
Klinisk medisinske fag: 750
Leukocytes (neutrophilic)
Lupus
Lupus nephritis
Medical disciplines: 700
Medisinske Fag: 700
Nephritis
Neutrophils
Phenotypes
Reumatologi: 759
Rheumatology: 759
Risk factors
Serology
Systemic lupus erythematosus
VDP
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Summary:Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (n=107). FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test. Clinical and serological data were then analyzed for their association with FCGR3B CN. Low FCGR3B CN (2). In multivariate analyses, LN was independently associated with anti-C1q-Ab levels (P=0.03) and low FCGR3B CN (P=0.09). We conclude that the susceptibility for LN in patients with low FCGR3B CN is linked to increased levels of pathogenic autoantibodies.
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2013/750814