Current View on the Mechanisms of Alcohol-Mediated Toxicity

Alcohol is a psychoactive substance that is widely used and, unfortunately, often abused. In addition to acute effects such as intoxication, it may cause many chronic pathological conditions. Some of the effects are very well described and explained, but there are still gaps in the explanation of em...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-09, Vol.22 (18), p.9686
Main Authors: Birková, Anna, Hubková, Beáta, Čižmárová, Beáta, Bolerázska, Beáta
Format: Article
Language:English
Subjects:
acetaldehyde
Acetaldehyde - metabolism
Acute effects
Alcohol Dehydrogenase - genetics
Alcohol Dehydrogenase - metabolism
Alcohol Drinking - adverse effects
Alcohol-Related Disorders - etiology
Alcohol-Related Disorders - metabolism
Alcoholism
Degradation products
Dehydrogenases
Enzymes
Ethanol
Ethanol - adverse effects
Ethanol - metabolism
Ethanol - toxicity
Gene Expression Regulation, Enzymologic
Humans
Intoxication
Liver
Metabolic Networks and Pathways
Metabolism
Metabolites
metabolization
Organ Specificity
Oxidation
Oxidative Stress
Review
Toxicity
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Summary:Alcohol is a psychoactive substance that is widely used and, unfortunately, often abused. In addition to acute effects such as intoxication, it may cause many chronic pathological conditions. Some of the effects are very well described and explained, but there are still gaps in the explanation of empirically co-founded dysfunction in many alcohol-related conditions. This work focuses on reviewing actual knowledge about the toxic effects of ethanol and its degradation products.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22189686