Factors associated with mortality among patients with necrotizing soft tissue infections: An analysis of 4597 cases using the Diagnosis Procedure Combination Database

•The mortality of necrotizing soft tissue infections (NSTI) in the DPC database was 6.9%.•Older age and lower BMI were high risk factors for mortality in NSTI.•Sex difference and diabetes at admission had no effect on mortality of NSTI. This study aimed to determine the factors associated with morta...

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Bibliographic Details
Published in:International journal of infectious diseases 2021-01, Vol.102, p.73-78
Main Authors: Suzuki, Hitoshi, Muramatsu, Keiji, Kubo, Tatsuhiko, Kawasaki, Makoto, Fujitani, Teruaki, Tsukamoto, Manabu, Uchida, Soshi, Fujino, Yoshihisa, Matsuda, Shinya, Sakai, Akinori
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
anti-MRSA antibiotic
antithrombin
body mass index
Cross-Sectional Studies
Diagnosis Procedure Combination Database
Female
Hospitalization
Humans
in-hospital mortality
Japan
Logistic Models
Male
Methicillin-Resistant Staphylococcus aureus - drug effects
Middle Aged
necrotizing soft tissue infection
Sepsis - diagnosis
Sepsis - drug therapy
Soft Tissue Infections - drug therapy
Soft Tissue Infections - epidemiology
Soft Tissue Infections - mortality
Staphylococcal Infections - epidemiology
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Summary:•The mortality of necrotizing soft tissue infections (NSTI) in the DPC database was 6.9%.•Older age and lower BMI were high risk factors for mortality in NSTI.•Sex difference and diabetes at admission had no effect on mortality of NSTI. This study aimed to determine the factors associated with mortality among patients with necrotizing soft tissue infection (NSTI) in Japan using inpatient data from the Diagnosis Procedure Combination (DPC) Database. We conducted a cross-sectional study using a population retrieved from the Japanese DPC inpatient database of patients who underwent surgical operations from 2014 through 2017. The associations between the covariates and mortality were estimated using multivariate logistic regression models. In total, 4597 patients were registered in this study, with an overall mortality rate of 6.9%. Multilevel logistic regression analysis revealed that higher age, lower body mass index (BMI 
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2020.10.019