Frequency of the MDR1 mutant allele associated with multidrug sensitivity in dogs from Brazil

To date, a 4-bp deletion in the MDR1 gene has been detected in more than ten dog breeds, as well as in mixed breed dogs, in several countries, however information regarding this mutation in dogs from Brazil is lacking. For this reason, 103 Collies, 77 Border Collies, 76 Shetland Sheepdogs, 20 Old En...

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Bibliographic Details
Published in:Veterinary medicine (Auckland) 2015-01, Vol.6 (default), p.111-117
Main Authors: Monobe, Marina M, Junior, João P Araujo, Lunsford, Kari V, Silva, Rodrigo C, Bulla, Camilo
Format: Article
Language:English
Subjects:
Allelomorphism
Deoxyribonucleic acid
DNA
Dogs
Drug resistance
Drug therapy
Gene mutations
Genetic aspects
Genotype & phenotype
Glycoproteins
Health aspects
Identification and classification
Mutation
Original Research
Polymerase chain reaction
Polymorphism
Population
Population genetics
Properties
Veterinary colleges
Veterinary medicine
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Summary:To date, a 4-bp deletion in the MDR1 gene has been detected in more than ten dog breeds, as well as in mixed breed dogs, in several countries, however information regarding this mutation in dogs from Brazil is lacking. For this reason, 103 Collies, 77 Border Collies, 76 Shetland Sheepdogs, 20 Old English Sheepdogs, 55 German Shepherds, 16 Australian Shepherds, and 53 Whippets from Brazil were screened for the presence of the mutation. The heterozygous mutated genotype, MDR1 (+/-), frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 50.5% (95% CI =41.1%-59.9%), 31.3% (95% CI =8.6%-53.2%), and 15.8% (95% CI =7.7%-23.9%), respectively. Homozygous mutated genotype, MDR1 (-/-), was detected only in Collies 35.9%. The MDR1 allele mutant frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 61.2% (95% CI =54.8%-67.5%), 15.6% (95% CI =3.1%-28.2%), and 7.9% (95% CI =3.7%-12.1%), respectively. Additionally, even free of the mutant allele, the maximum mutant prevalence (MMP) in that population, with 95% CI, was 3.8%, 5.2%, 5.4%, and 13.8% for Border Collies, German Shepherds, Whippets, and Old English Sheepdogs, respectively. In this way, this information is important, not only for MDR1 genotype-based breeding programs and international exchange of breeding animals of predisposed breeds, but also for modification of drug therapy for breeds at risk.
ISSN:2230-2034
2230-2034
DOI:10.2147/VMRR.S72373