Course of postoperative relapse in non‐small cell lung cancer is strongly associated with post‐progression survival

Background For early‐stage non‐small cell lung cancer (NSCLC), surgical resection is considered the most effective treatment strategy and curative treatment. Unfortunately, even after complete resection, almost half of all patients with stage I–IIIA NSCLC relapse and die. Although the possibility of...

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Bibliographic Details
Published in:Thoracic cancer 2021-10, Vol.12 (20), p.2740-2748
Main Authors: Imai, Hisao, Onozato, Ryoichi, Kaira, Kyoichi, Kawashima, Sayaka, Masubuchi, Ken, Nagashima, Toshiteru, Tajima, Kohei, Minato, Koichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cancer therapies
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - surgery
Chemotherapy
Committees
Disease Progression
Disease-Free Survival
Epidermal growth factor
Ethics
Female
Humans
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - surgery
Male
Medical prognosis
Metastasis
Middle Aged
non‐small cell lung cancer
Original
overall survival
Patients
postoperative recurrence
post‐progression survival
Radiation therapy
relapse‐free survival
Surgery
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Summary:Background For early‐stage non‐small cell lung cancer (NSCLC), surgical resection is considered the most effective treatment strategy and curative treatment. Unfortunately, even after complete resection, almost half of all patients with stage I–IIIA NSCLC relapse and die. Although the possibility of a cure for postoperative recurrence of NSCLC is significantly low, the course of subsequent treatment can possibly affect overall survival (OS). Here, we examined the association of relapse‐free survival (RFS) and post‐progression survival (PPS) with OS in patients with postoperative recurrence of NSCLC. Methods We evaluated 128 patients with NSCLC who underwent complete resection between January 2007 and December 2018. The association between RFS and PPS on OS was examined at the patient level. Results Spearman's rank correlation and linear regression analyses revealed that PPS was strongly correlated with OS (r = 0.83, p 
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.14119