Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats

Background: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. Methods: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCO...

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Bibliographic Details
Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2023-09, Vol.16, p.2717-2732
Main Authors: Zheng, Pingping, Lu, Yating, Tang, You, Xu, Fudong, Wang, Lin, Qian, Rui, Hui, Cancan, Xu, Qian, He, Jianle, Deng, Datong
Format: Article
Language:English
Subjects:
acarbose
Body weight
Brain
Dextrose
Glucose
Glycoproteins
Insulin
Insulin resistance
kisspeptin
Luteinizing hormone
Metformin
Original Research
pioglitazone
Pituitary hormones
polycystic ovary syndrome
pcos
Stein-Leventhal syndrome
Testosterone
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Summary:Background: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. Methods: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCOS rats with metformin, pioglitazone, and acarbose, and we then observed changes in weight, estrus, glucose tolerance, insulin resistance, sex hormones, and hypothalamic kiss1 expression. Results: PCOS rats exhibited increased body weight, abnormal estrous cycle, impaired glucose tolerance, insulin resistance, increased testosterone level, increased luteinizing hormone level, and increased Kiss1 expression in the hypothalamus. However, intervention with metformin, pioglitazone, and acarbose improved the reproductive and metabolic disorders as well as reduced hypothalamic Kiss1 expression. Conclusion: The expression of hypothalamic Kiss1 may play an important role in the pathogenesis of PCOS. Metformin, pioglitazone, and acarbose may reduce the expression of hypothalamic Kiss1 by improving insulin resistance, thereby improving reproductive and metabolic disorders in PCOS rats. Keywords: polycystic ovary syndrome, PCOS, kisspeptin, metformin, pioglitazone, acarbose
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S421911