Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa’s Skin Infection: A Systematic Review

Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often in...

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Bibliographic Details
Published in:International journal of nanomedicine 2024-08, Vol.19, p.7895-7926
Main Authors: Quinones-Vico, Maria I, Ubago-Rodnguez, Ana, Fernandez-Gonzalez, Ana, Sanabria-de la Torre, Raquel, Sierra-Sanchez, Alvaro, Montero-Vilchez, Trinidad, Sanchez-Diaz, Manuel, Arias, Jose L, Arias-Santiago, Salvador
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Care and treatment
Drug resistance
Drug therapy
Health aspects
hydrogel
Infection
Medical research
Medicine, Experimental
Nanoparticles
p.aeruginosa
Pseudomonas aeruginosa
Review
Skin
skin infection
wound dressing
Wounds and injuries
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Summary:Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often involve the topical or systemic application of antibiotics, which can lead to systemic toxicity and the development of drug resistance. The combination of wound dressings that promote wound healing with nanoparticles (NPs) represents a revolutionary strategy for optimizing the safety and efficacy of antibiotics. This review assesses a systematic search to identify the latest approaches where the evaluation of wound dressings loaded with antibiotic NPs is conducted. The properties of NPs, the features of wound dressings, the antimicrobial activity and biocompatibility of the different strategies are analyzed. The results indicate that most research in this field is focused on dressings loaded with silver NPs (57.1%) or other inorganic materials (22.4%). Wound dressings loaded with polymeric NPs and carbon-based NPs represent 14.3% and 6.1% of the evaluated studies, respectively. Nevertheless, there are no clinical trials that have evaluated the efficacy of NPs-loaded wound dressings in patients. Further research is required to ensure the safety of these treatments and to translate the findings from the bench to the bedside. Keywords: hydrogel, skin infection, wound dressing, P. aeruginosa, nanoparticles
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S469724