Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin

We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid g...

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Bibliographic Details
Published in:TheScientificWorld 2011-01, Vol.2011 (2011), p.1-9
Main Authors: Selgas, Rafael, Peces, Carlos, Cuesta-López, Emilio, Peces, Ramón
Format: Article
Language:English
Subjects:
Adult
Angiomyolipoma - complications
Angiomyolipoma - drug therapy
Angiomyolipoma - surgery
Angiomyolipoma - therapy
Care and treatment
Case Report
Female
Health aspects
Humans
Kidney cancer
Kidney Neoplasms - complications
Kidney Neoplasms - drug therapy
Kidney Neoplasms - surgery
Kidney Neoplasms - therapy
Lung diseases
Lymphangioleiomyomatosis - complications
Lymphangioleiomyomatosis - drug therapy
Lymphangioleiomyomatosis - surgery
Lymphangioleiomyomatosis - therapy
Physiological aspects
Pregnancy
Pregnancy Complications, Neoplastic - drug therapy
Pregnancy Complications, Neoplastic - surgery
Pregnancy Complications, Neoplastic - therapy
Rapamycin
Sirolimus - therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
Tumors
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Description
Summary:We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2011/263137