Characteristic calcification behavior of five surgical aortic valve bioprostheses models: An in vitro study

Background and Aims The durability of surgical aortic valve bioprostheses (SAV) is limited by the calcification of the leaflets, which results in degeneration. In clinical routine, there seems to be substantial variability in the degeneration of specific SAV models. Our study aims to establish an in...

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Bibliographic Details
Published in:Health science reports 2024-08, Vol.7 (8), p.e2304-n/a
Main Authors: Sadat, Najla, Lojenburg, John H., Scharfschwerdt, Michael, Klinger, Matthias, Fujita, Buntaro, Ensminger, Stephan
Format: Article
Language:English
Subjects:
bioprostheses degeneration
Calcification
Cardiology
Crystals
durability testing
Endocrinology and Metabolic Disorders
Epidemiology
General Medicine
Genetics and Genomics
Hydrochloric acid
Hydroxyapatite
Immunology
Infectious Diseases
Medical Education
Original Research
Potassium
Prostheses
Sports Medicine
structural valve deterioration
Surgery
surgical aortic valve
Variance analysis
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Summary:Background and Aims The durability of surgical aortic valve bioprostheses (SAV) is limited by the calcification of the leaflets, which results in degeneration. In clinical routine, there seems to be substantial variability in the degeneration of specific SAV models. Our study aims to establish an in vitro calcification model for prosthetic valves, characterizing the calcification behavior of different SAVs. Methods Five commercially available SAV models (Epic™ Supra, Freestyle®, Intuity®, Perimount®, and Trifecta™) were perfused with double‐distilled water and physiological buffer with a defined calcium concentration (CaCl2 = 1.5 mM) at 37°C over 32.9 million cycles in a Hi‐Cycle tester which corresponds to approximately 1 patient‐year (calcified group). Untreated prosthetic valves served as the negative control group (noncalcified group). Calcium titration, scanning electron microscopy (SEM), histological examination, and tissue thickness measurements were performed to evaluate noncalcified and calcified SAVs (n = 10). Results Treatment in the Hi‐Cycle tester with calcification buffer maintained significantly higher calcium absorption of SAVs compared to the control group (p 
ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.2304