Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

This report presents a case of prosthetic hip infection caused by Staphylococcus argenteus, a potentially overlooked etiology of prosthetic joint infections (PJIs). Whole-genome sequencing showed that the S. argenteus isolate was an ST2250 and clustered within other CC2250 isolates, the largest clon...

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Bibliographic Details
Published in:Journal of bone and joint infection 2020-05, Vol.5 (4), p.172-175
Main Authors: Söderquist, Bo, Wildeman, Peter, Stenmark, Bianca, Stegger, Marc
Format: Article
Language:English
Subjects:
Analysis
antimicrobial agents
Development and progression
genome analysis
Genomes
Genomics
Health aspects
Infection
Prostheses and implants
prosthetic joint infections
Short Research Communication
Staphylococcal infections
Staphylococcus argenteus
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Summary:This report presents a case of prosthetic hip infection caused by Staphylococcus argenteus, a potentially overlooked etiology of prosthetic joint infections (PJIs). Whole-genome sequencing showed that the S. argenteus isolate was an ST2250 and clustered within other CC2250 isolates, the largest clonal group of S. argenteus. This sequence type is prevalent and may be associated with invasive infections. The present isolate was phenotypically fully susceptible to all tested antimicrobial agents and genome analysis did not detect any resistance genes, nor were any staphylococcal cassette chromosome residues detected. Despite initial appropriate management with debridement and biofilm-active antibiotics, the outcome was unfavorable with recurrence and a persistent infection treated with suppressive antibiotics. Regarding the repertoire of genomic traits for virulence in S. argenteus, PJIs caused by this bacterium should be treated accordingly as Staphylococcus aureus PJIs.
ISSN:2206-3552
2206-3552
DOI:10.7150/jbji.44848