Microfluidic-Based Single-Cell Study: Current Status and Future Perspective

Investigation of cell behavior under different environments and manual operations can give information in specific cellular processes. Among all cell-based analysis, single-cell study occupies a peculiar position, while it can avoid the interaction effect within cell groups and provide more precise...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-09, Vol.23 (9), p.2347
Main Authors: Wu, Haiwa, Zhu, Jing, Huang, Yao, Wu, Daming, Sun, Jingyao
Format: Article
Language:English
Subjects:
Animals
Cell culture
Humans
Information processing
manufacturing
Mass production
Methods
Microfluidic Analytical Techniques - instrumentation
Microfluidics
Pathology
Pharmacology
polymeric
Polymers
Polymers - chemistry
Researchers
Review
Single-Cell Analysis - methods
single-cell study
Stem cells
Tissue engineering
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Summary:Investigation of cell behavior under different environments and manual operations can give information in specific cellular processes. Among all cell-based analysis, single-cell study occupies a peculiar position, while it can avoid the interaction effect within cell groups and provide more precise information. Microfluidic devices have played an increasingly important role in the field of single-cell study owing to their advantages: high efficiency, easy operation, and low cost. In this review, the applications of polymer-based microfluidics on cell manipulation, cell treatment, and cell analysis at single-cell level are detailed summarized. Moreover, three mainly types of manufacturing methods, i.e., replication, photodefining, and soft lithography methods for polymer-based microfluidics are also discussed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23092347