Undiagnosed gastric adenocarcinoma causing progressive respiratory failure

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. Pulmonary tumor emboli and associated fibrous intimal hyperplasia cause widespread pulmonary vascular stenosis/occlusion, which in turn increase pulmonary vascular resistance and lead to pulmonary hypertension....

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Bibliographic Details
Published in:JGH open 2022-10, Vol.6 (10), p.730-731
Main Authors: Clayton‐Chubb, Daniel, Chan, Ewan, Schneider, Daniel, Riley, Brooke, Dwyer, Jeremy
Format: Article
Language:English
Subjects:
carcinogenesis and metastasis
Case Report
Case Reports
Chemotherapy
Dyspnea
endoscopy
Gastric cancer
gastroenterology
Heart failure
Hyperplasia
Metastasis
Patients
Pulmonary hypertension
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Summary:Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. Pulmonary tumor emboli and associated fibrous intimal hyperplasia cause widespread pulmonary vascular stenosis/occlusion, which in turn increase pulmonary vascular resistance and lead to pulmonary hypertension. Gastric cancer is the most common underlying malignancy that leads to PTTM, and patients may present with dyspnea or other features of pulmonary hypertension prior to the diagnosis of cancer. In this short report, we describe a case of pulmonary hypertension due to gastric cancer associated PTTM. Endoscopic and histopathologic findings are shown, and a brief review of the literature is presented. Gastric adenocarcinoma is the most common cause of pulmonary tumor thrombotic microangiopathy (PTTM). This case describes the clinical course of a patient presenting with pulmonary hypertension due to PTTM, which developed from undiagnosed signet cell gastric adenocarcinoma, and provides endoscopic and histopathological confirmation of the diagnosis.
ISSN:2397-9070
2397-9070
DOI:10.1002/jgh3.12814