Association between the triglyceride–glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross‐sectional study

• Published in: Journal of diabetes investigation 2021-04, Vol.12 (4), p.557-565
• Main Authors: Liu, Li, Xia, Rui, Song, Xiaoqing, Zhang, Benping, He, Wentao, Zhou, Xinrong, Li, Shengzhong, Yuan, Gang
• Format: Article
• Language: English
• Subjects: Albumin; Blood Glucose; Blood pressure; Cholesterol; Correlation analysis; Creatinine; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Diabetic nephropathy; Diabetic retinopathy; Fasting; Female; Glomerular filtration rate; Glucose; Hemoglobin; Homeostasis; Humans; Hypertension; Insulin; Insulin Resistance; Kidney diseases; Laboratories; Liver diseases; Male; Middle Aged; Multiple regression analysis; Nephropathy; Original; Pathogenesis; Peptides; Peripheral neuropathy; Retrospective Studies; Risk factors; Triglycerides; Triglycerides - blood; Triglyceride–glucose index; Uric acid; Variables
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.13371

Aims/Introduction The triglyceride–glucose (TyG) index has been proposed as a reliable and simple marker of insulin resistance. We investigated the association between TyG index and diabetic nephropathy (DN) in patients with type 2 diabetes. Materials and Methods A consecutive case series of 682 adult patients with type 2 diabetes hospitalized in the Department of Endocrinology at the Tongji Hospital (Wuhan, Hubei, China) from January 2007 to December 2009 was included in this cross‐sectional analysis. Receiver operating characteristics curve analysis, correlation analysis and multiple logistic regression analysis were carried out. Results A total of 232 (34.0%) participants were identified with DN. Compared with the non‐DN group, the DN group had longer disease duration, and higher bodyweight, systolic blood pressure, diastolic blood pressure, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, 24 h‐urinary albumin, TyG index and homeostasis model assessment 2 estimates for insulin resistance (HOMA2‐IR; P 9.66 showed a higher area under the receiver operating characteristic curve of 0.67 (P = 0.002) than HOMA2‐IR (area under the curve 0.61, P = 0.029) on receiver operating characteristic curve analysis for DN identification. Additionally, the TyG index positively correlated with the levels of metabolic indicators (bodyweight, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, fasting glucose and HOMA2‐IR) and natural logarithmic 24 h‐urinary albumin (P