Efficacy and Safety of Misoprostol Administered Rectally Compared with Oxytocin for the Prevention of Postpartum Hemorrhage

Background: The foremost cause of maternal morbidity and mortality in third-world countries is Post-Partum Hemorrhage (PPH). To prevent PPH, often Misoprostol is used. This study aimed to find out the efficacy and safety profile of Misoprostol when administered rectally in comparison to oxytocin, to...

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Bibliographic Details
Published in:Pakistan journal of medicine and dentistry 2024-05, Vol.11 (4)
Main Authors: Shama Chaudhry, Hina Rajani, Rahima Rais, Habiba Sharaf Ali
Format: Article
Language:English
Online Access:Get full text
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Summary:Background: The foremost cause of maternal morbidity and mortality in third-world countries is Post-Partum Hemorrhage (PPH). To prevent PPH, often Misoprostol is used. This study aimed to find out the efficacy and safety profile of Misoprostol when administered rectally in comparison to oxytocin, to avoid the incidence of PPH. Methods: This quasi-experimental study on n=72 patients were performed at Ziauddin University and Hospital Karachi for 6 months (2021). The patients were divided into two groups. Oxytocin (10 IU) was administered intramuscularly to Group A(n=36) while 400ug of Misoprostol was given to group B(n=36) rectally, at the time of delivery. The level of hemoglobin was checked at the time of admission and 24 hours after delivery and side effects were also monitored. Chi-square and t-test were applied between both groups and a p-value
ISSN:2313-7371
2308-2593
DOI:10.36283/PJMD11-4/010