JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region

JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2016-07, Vol.20 (4), p.360-364
Main Authors: Cayres-Vallinoto, Izaura Maria Vieira, Vallinoto, Antonio Carlos Rosário, Pena, Giselle Priscila dos Anjos, Azevedo, Vânia Nakauth, Machado, Luiz Fernando Almeida, Ishak, Marluísa de Oliveira Guimarães, Ishak, Ricardo
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - urine
AIDS-Related Opportunistic Infections - virology
Brazil
Brazilian Amazon region
Care and treatment
CD4 Lymphocyte Count
Child
Co-infection
Coinfection - virology
Comorbidity
Cross-Sectional Studies
Development and progression
DNA, Viral - urine
Female
Forecasts and trends
Health aspects
HIV infections
HIV-1
Humans
INFECTIOUS DISEASES
JC Virus - genetics
JC Virus - isolation & purification
JCV
Leukoencephalopathy, Progressive Multifocal - diagnosis
Male
Middle Aged
Original
Polymerase Chain Reaction
Polyomavirus
Viral Load
Young Adult
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Summary:JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease. Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215bp) and IG (610bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected subjects. Apparently, there was no significant difference between mono- (HIV-1 only) and co-infected (HIV-1/JCV) subjects regarding their TCD4+/TCD8+ lymphocyte counts or HIV-1 plasma viral load. Self admitted seizures, hearing and visual loses were not significantly different between the two groups.
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1016/j.bjid.2016.05.005