Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population

• Published in: Frontiers in endocrinology (Lausanne) 2018-11, Vol.9, p.709-709
• Main Authors: Zhou, Zixing, Wang, Lijun, Wen, Zihao, Zheng, Shaoling, Ye, Xiaohong, Liu, Dandan, Wu, Jing, Zou, Xiaoqian, Liu, Yumei, Wang, Yao, Dong, Shirui, Huang, Xiuxia, Du, Xiuben, Zhu, Kehui, Chen, Xiaojing, Huang, Shiqi, Zeng, Chengli, Han, Yajing, Zhang, Baohuan, Nie, Lihong, Yang, Guang, Jing, Chunxia
• Format: Article
• Language: English
• Subjects: AIM2; ASC; Endocrinology; NLRP3; promoter methylation; T2DM; vascular complication
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2018.00709

To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM. A case-control study was used to determine the association between population characteristics, the methylation level in the promoter region of the NLRP3, AIM2, and ASC genes and T2DM and vascular complications. A mediating effect among genes-environment-T2DM and the interaction of gene-gene or gene-environment factors was explored. In the logistic regression model with adjusted covariants, healthy people with lower total methylation levels in the AIM2 promoter region exhibited a 2.29-fold [OR: 2.29 (1.28~6.66), = 0.011] increased risk of developing T2DM compared with higher-methylation individuals. T2DM patients without any vascular complications who had lower methylation levels (