Importance of the COVID-19 Vaccine Booster Dose in Protection and Immunity

Background: There is debate on the necessity of booster doses of COVID-19 vaccination, especially in countries with limited resources. Methods: This cross-sectional study was conducted in a referral laboratory in Tehran, Iran. The level of COVID-19 antibodies was measured and compared between indivi...

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Bibliographic Details
Published in:Vaccines (Basel) 2022-10, Vol.10 (10), p.1708
Main Authors: Abdollahi, Alireza, Afsharyzad, Yeganeh, Vaezi, Atefeh, Meysamie, Alipasha
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Antibody response
Autoimmune diseases
booster dose
Chicken pox
Comparative analysis
Coronaviruses
COVID-19
COVID-19 vaccines
Cross-sectional studies
Diabetes
Ethylenediaminetetraacetic acid
Health aspects
Hospitals
Immune response
Immunoglobulin G
Infections
Influenza
Influenza vaccines
Laboratories
neutralizing antibody
Population
Public health
RBD antibody
Regression analysis
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
spike antibody
Statistical analysis
Vaccination
Vaccines
Viral infections
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Summary:Background: There is debate on the necessity of booster doses of COVID-19 vaccination, especially in countries with limited resources. Methods: This cross-sectional study was conducted in a referral laboratory in Tehran, Iran. The level of COVID-19 antibodies was measured and compared between individuals regarding the number of COVID-19 vaccine shots. Results: In this study, 176 individuals with a mean age of 36.3 (±11.7) years participated. A total of 112 individuals received two doses of the COVID-19 vaccine, and 64 individuals received three doses. Level of all antibodies was higher in those who received three doses than in those who received two doses of the COVID-19 vaccine. Considering the SARS-CoV-2 Spike IgG, the difference was not statistically significant but for the SARS-CoV-2 RBD IgG and SARS-CoV-2 NAB the difference was statistically significant. Regarding to the background variables, receiving influenza vaccine in the past year, history of autoimmune diseases and past medical history of chicken pox showed a significant association with the number of vaccine doses received. Their effects on the outcome variables assessed with multivariate logistic regression analysis. Conclusion: The results of our study show that a booster dose of the COVID-19 vaccine enhances the antibody response.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10101708