Nanoemulsions of Jasminum humile L. and Jasminum grandiflorum L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects

Unprecedented nanoemulsion formulations (NE) of and essential oils (EO) were prepared, and examined for their cytotoxic and antiviral activities. NE characterization and stability examination tests were performed to ensure formula stability. The antiviral activity was determined against hepatitis A...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-06, Vol.27 (11), p.3639
Main Authors: Mansour, Khaled Ahmed, El-Neketi, Mona, Lahloub, Mohamed-Farid, Elbermawi, Ahmed
Format: Article
Language:English
Subjects:
Acyclovir
Antiviral activity
Antiviral agents
Biological activity
Brain cancer
Breast cancer
Cytotoxicity
Doxorubicin
Essential oils
Formulations
grandiflorum
HAV
Hepatitis
Hepatitis A
Herpes simplex
Herpes viruses
HSV-1
humile
Jasminum
Leukemia
nanoemulsion
Nanoemulsions
Nanotechnology
Oils & fats
Penicillin
Selectivity
Stability
Surfactants
Tumor cell lines
Vero cells
Viruses
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Summary:Unprecedented nanoemulsion formulations (NE) of and essential oils (EO) were prepared, and examined for their cytotoxic and antiviral activities. NE characterization and stability examination tests were performed to ensure formula stability. The antiviral activity was determined against hepatitis A (HAV) and herpes simplex type-1 (HSV-1) viruses using MTT assay, while the cytotoxic potential was determined against liver (HepG-2), breast (MCF-7), leukemia (THP-1) cancer cell lines and normal Vero cells. Statistical significance was determined in comparison with doxorubicin as cytotoxic and acyclovir as antiviral standard drugs. GC-MS analysis indicated twenty four compounds in the EO of and seventeen compounds in the EO of . Biological investigations of pure EOs revealed weak cytotoxic and antiviral effects. Nevertheless, their NE formulations exhibited high biological value as cytotoxic and antiviral agents. NE formulations also showed feasible selectivity index for the viral-infected and cancer cells (especially HepG-2) than normal Vero cells. Both nanoemulsions showed lower IC than standard doxorubicin against HepG-2 (26.65 and 22.58 vs. 33.96 μg/mL) and MCF-7 (36.09 and 36.19 vs. 52.73 μg/mL), respectively. The study results showed the dramatic effect of nanoemulsion preparation on the biological activity of EOs and other liposoluble phytopharmaceuticals.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27113639