Dynamic changes in clinical and CT characteristics of COVID-19 cases with different exposure histories: a retrospective study

• Published in: BMC infectious diseases 2020-08, Vol.20 (1), p.567-567, Article 567
• Main Authors: Li, Ruili, Liu, Guangxue, Huang, Xiaojie, Jia, Cuiyu, Xia, Zhenying, Song, Wenyan, Li, Xueqin, Wang, Xing, Li, Hongjun
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albumin; Albumins; Betacoronavirus; C-reactive protein; C-Reactive Protein - analysis; Clinical characteristic; Comparative analysis; Coronavirus Infections - diagnostic imaging; Coronavirus Infections - virology; Coronaviruses; Correlation analysis; Cough; Cough - epidemiology; Cough - virology; COVID-19; Development and progression; Different exposure histories; Disease; Disease Progression; Dynamic change; Epidemiology; Exposure; Female; Fever; Fever - epidemiology; Fever - virology; Follow-Up Studies; Globulins; Humans; Indicators; Infectious diseases; Influenza; Laboratories; Lymphocytes; Lymphopenia; Lymphopenia - diagnosis; Male; Medical imaging; Medical research; Middle Aged; Pandemics; Pathogenicity; Pathogens; Patient Discharge; Patients; Pneumonia; Pneumonia, Viral - diagnostic imaging; Pneumonia, Viral - virology; Prognosis; Retrospective Studies; SARS-CoV-2; Serum Albumin, Human - analysis; Serum Globulins - analysis; Severe acute respiratory syndrome coronavirus 2; Tomography, X-Ray Computed; Travel; Viral diseases
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-020-05306-x

To assess the dynamic changes in clinical and CT characteristics of COVID-19 patients with different epidemiology histories. Fifty-three discharged COVID-19 patients were enrolled at Beijing YouAn Hospital, Capital Medical University, between January 21 and March 10, 2020. Spearman correlation analysis was performed between CT scores and laboratory indicators. Patients were divided into the Wuhan group (lived in or with travel to Wuhan, numbering 30 cases) and non-Wuhan group (close contacts or unknown exposure, totaling 23 cases). The CT and laboratory findings were compared between and within groups during the clinical process. Fever (88.7%), cough (64.2%), fatigue (34%), and abnormal laboratory indicators, including lymphopenia, reduced albumin, albumin/globulin (A/G), and elevated C-reactive protein (CRP), were mainly observed. Subpleural ground-glass opacities (86.8%) were usually detected at admission. The CT scores were highly correlated with lymphocytes, CRP, albumin, and A/G at initial and follow-ups (all p