Ethics of alternative trial designs and methods in low-resource settings

This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeting were the use of cluster randomized trials, stepped-wedge cluster randomized trials, and...

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Bibliographic Details
Published in:Current controlled trials in cardiovascular medicine 2019-12, Vol.20 (Suppl 2), p.705-705, Article 705
Main Authors: van der Graaf, Rieke, Cheah, Phaik Yeong
Format: Article
Language:English
Subjects:
Adaptive trials
Alternative trial designs
Bioethics
Clinical trials
Cluster randomized trials
Consent
Controlled human challenge studies
Design
Ethics
Health aspects
Health care
Infection
Infections
International organizations
Intervention
Malaria
Medical research
Methods
Public health
Stepped wedge cluster randomized trials
Towns
Vaccines
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Summary:This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeting were the use of cluster randomized trials, stepped-wedge cluster randomized trials, and controlled human infection models in research conducted in low-resource settings. The editorial sets out which ethical issues may arise in the context of alternative trial designs and describes the articles in this issue that addresses some or more of the ethical issues, such as justification of the research design, risk-benefit evaluations and consent.
ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-019-3841-2