Curcumin and Nanocurcumin Oral Supplementation Improve Muscle Healing in a Rat Model of Surgical Muscle Laceration

To compare the effects of curcumin and nanocurcumin oral supplementation on the muscle healing rate of an animal model of surgical muscle laceration. Thirty-two male adult rats were randomly divided into sham, control, curcumin, and nanocurcumin groups. Partial transection of the gastrocnemius muscl...

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Bibliographic Details
Published in:Bulletin of emergency & trauma 2019-07, Vol.7 (3), p.292-299
Main Authors: Kazemi-Darabadi, Siamak, Nayebzadeh, Ramin, Shahbazfar, Amir Ali, Kazemi-Darabadi, Faranak, Fathi, Ezzatollah
Format: Article
Language:English
Subjects:
Curcumin
Muscle laceration
Nano particles
Original
Rat
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Summary:To compare the effects of curcumin and nanocurcumin oral supplementation on the muscle healing rate of an animal model of surgical muscle laceration. Thirty-two male adult rats were randomly divided into sham, control, curcumin, and nanocurcumin groups. Partial transection of the gastrocnemius muscle was made in the right limb of the control and treatment groups. The sham and control groups received normal saline, curcumin group received 500 mg/kg of curcumin and nanocurcumin group received 100 mg curcumin-loaded nanomicelles orally every day. They euthanized two weeks later and the specimens were stained by hematoxylin-eosin (H&E) and Masson's trichrome methods. Aspartate transaminase (AST) and creatine phosphokinase (CPK) were measured in blood samples. The percentage of collagen fibers in the nanocurcumin group was significantly lesser than the control and curcumin groups (p
ISSN:2322-2522
2322-3960
2322-2522
2322-3960
DOI:10.29252/beat-0703013