Donor artery stenosis interactions with diastolic blood pressure on coronary collateral flow in type 2 diabetic patients with chronic total occlusion

• Published in: Cardiovascular diabetology 2018-06, Vol.17 (1), p.76-76, Article 76
• Main Authors: Shen, Ying, Yang, Zhen Kun, Hu, Jian, Wang, Xiao Qun, Dai, Yang, Zhang, Su, Zhang, Rui Yan, Lu, Lin, Ding, Feng Hua, Shen, Wei Feng
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Angina pectoris; Aorta; Arterial Pressure; Atherosclerosis; Blood pressure; Cardiology; Cardiovascular disease; Case-Control Studies; Chronic total occlusion; Clinical outcomes; Collateral; Collateral Circulation; Coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - etiology; Coronary Artery Disease - physiopathology; Coronary Circulation; Coronary Occlusion - diagnostic imaging; Coronary Occlusion - etiology; Coronary Occlusion - physiopathology; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - etiology; Coronary Stenosis - physiopathology; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - etiology; Diabetic Angiopathies - physiopathology; Female; Heart attacks; Heart failure; Heart surgery; Humans; Hypertension; Intervention; Ischemia; Laboratories; Male; Medical imaging; Middle Aged; Occlusion; Original Investigation; Patients; Prognosis; Risk Factors; Severity of Illness Index; Stenosis
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-018-0724-x

We investigated whether and to what extent stenosis of predominant collateral donor artery (PCDA) affects coronary collateral flow in relation to blood pressure (BP) in type 2 diabetic patients with chronic total occlusion (CTO). Collateral flow index (CFI) as derived from intracoronary pressure distal to occluded segment and mean aortic pressure in 220 type 2 diabetic patients and 220 propensity score matched non-diabetic controls undergoing percutaneous coronary intervention for CTO. The severity of PCDA stenosis was graded according to lumen diameter narrowing. CFI decreased stepwise from mild to severe stenosis of the PCDA and was lower in diabetic patients with moderate or severe PCDA stenosis than in non-diabetic controls (0.36 ± 0.10 vs. 0.45 ± 0.08, P