The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM

Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous developmental problems, including intellectual disability, motor and speech delays, and seizures. Hitherto, over 30 MCPH causing genes ( MCPHs ) have been identified. Among these MCPHs...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-08, Vol.17, p.1242448-1242448
Main Authors: Wu, Xingxuan, Li, Zheng, Wang, Zhao-Qi, Xu, Xingzhi
Format: Article
Language:English
Subjects:
Amino acids
ASPM
cancer
Cell cycle
Cell division
Cell proliferation
DNA biosynthesis
DNA repair
Insects
Intellectual disabilities
Kinases
Localization
MCPH5
Microcephaly
Microencephaly
Neurogenesis
Neurons
Neuroscience
Proteins
Seizures
small brain
Standard deviation
Stem cells
Tumorigenesis
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Summary:Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous developmental problems, including intellectual disability, motor and speech delays, and seizures. Hitherto, over 30 MCPH causing genes ( MCPHs ) have been identified. Among these MCPHs , MCPH5 , which encodes abnormal spindle-like microcephaly-associated protein (ASPM), is the most frequently mutated gene. ASPM regulates mitotic events, cell proliferation, replication stress response, DNA repair, and tumorigenesis. Moreover, using a data mining approach, we have confirmed that high levels of expression of ASPM correlate with poor prognosis in several types of tumors. Here, we summarize the neurological and non-neurological functions of ASPM and provide insight into its implications for the diagnosis and treatment of MCPH and cancer.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1242448