Synthetic strategies for the preparation of γ-phostams: 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides

γ-Phostams include γ-phosphonolactams and γ-phosphinolactams and their fused derivatives, phosphorus analogues of γ-lactams. They are 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides and important biological five-membered azaphosphaheterocycles. They have been prepared through two major...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2022-07, Vol.18 (1), p.889-915
Main Author: Xu, Jiaxi
Format: Article
Language:English
Subjects:
azaphospholidine
azaphospholine
Chemistry
Chloride
Oxides
phosphinolactam
phosphonolactam
Phosphorus
Review
γ-phosphinolactam
γ-phosphonolactam
γ-phostam
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Summary:γ-Phostams include γ-phosphonolactams and γ-phosphinolactams and their fused derivatives, phosphorus analogues of γ-lactams. They are 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides and important biological five-membered azaphosphaheterocycles. They have been prepared through two major strategies of cyclizations and annulations. Cyclizations achieve ring construction through the formation of any bond in the ring, while annulations build the ring via [4 + 1] and [3 + 2] fashions with the simultaneous formation of two bonds. The review includes the synthesis of 1,2-azaphospholidine and 1,2-azaphospholine 2-oxides/sulfides and their fused derivatives.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.18.90