Bioactivity and Toxicity of Senna cana and Senna pendula Extracts

This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal Senna species extracts (Senna cana and Senna pendula) were also investigated. The eth...

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Published in:Biochemistry research international 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Silva, M. G. V., Silva, A. A. S., Pinto, C. C. C., Batista, F. L. A., Oliveira, I. R., Ferreira Júnior, J. M., Monteiro, J. A., de Morais, Selene Maia
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Aedes aegypti
Antioxidants
Artemia
Artemia salina
Biocompatibility
Biological activity
Ethanol
Fabaceae
Flavonoids
Flowers
Flowers & plants
Herbal medicine
Isoflavones
Leaves
Medicine, Botanic
Medicine, Herbal
Natural products
Phenolic compounds
Phenols
Phytochemicals
Polyphenols
Senna alata
Senna cana
Senna multijuga
Senna pendula
Senna reticulata
Toxicity
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creator Silva, M. G. V.
Silva, A. A. S.
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de Morais, Selene Maia
description This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal Senna species extracts (Senna cana and Senna pendula) were also investigated. The ethanol extract of the leaves of S. cana and the ethanol extract of the branches of S. pendula presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. For the inhibition of acetylcholinesterase, the hexane extract of the flowers of S. pendula presented the lowest IC50 value among the ethanol extracts of the leaves of S. cana and showed the best performance in some assays. The hexane extract of the leaves of S. pendula and the hexane extract of the branches of S. cana were moderate to Artemia salina Leach. In the quantification of phenols and flavonoids, the ethanol extract of the leaves of S. cana presented the best results. The ethanol extracts of the leaves of S. cana were found to be rich in antioxidants, phenolic compounds, and flavonoids. These results indicate the antioxidant potential of the extracts of Senna species and can be responsible for some of the therapeutic uses of these plants.
doi_str_mv 10.1155/2018/8074306
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G. V. ; Silva, A. A. S. ; Pinto, C. C. C. ; Batista, F. L. A. ; Oliveira, I. R. ; Ferreira Júnior, J. M. ; Monteiro, J. A. ; de Morais, Selene Maia</creator><contributor>Lorigan, Gary A. ; Gary A Lorigan</contributor><creatorcontrib>Silva, M. G. V. ; Silva, A. A. S. ; Pinto, C. C. C. ; Batista, F. L. A. ; Oliveira, I. R. ; Ferreira Júnior, J. M. ; Monteiro, J. A. ; de Morais, Selene Maia ; Lorigan, Gary A. ; Gary A Lorigan</creatorcontrib><description>This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal Senna species extracts (Senna cana and Senna pendula) were also investigated. The ethanol extract of the leaves of S. cana and the ethanol extract of the branches of S. pendula presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. For the inhibition of acetylcholinesterase, the hexane extract of the flowers of S. pendula presented the lowest IC50 value among the ethanol extracts of the leaves of S. cana and showed the best performance in some assays. The hexane extract of the leaves of S. pendula and the hexane extract of the branches of S. cana were moderate to Artemia salina Leach. In the quantification of phenols and flavonoids, the ethanol extract of the leaves of S. cana presented the best results. The ethanol extracts of the leaves of S. cana were found to be rich in antioxidants, phenolic compounds, and flavonoids. These results indicate the antioxidant potential of the extracts of Senna species and can be responsible for some of the therapeutic uses of these plants.</description><identifier>ISSN: 2090-2247</identifier><identifier>EISSN: 2090-2255</identifier><identifier>DOI: 10.1155/2018/8074306</identifier><identifier>PMID: 29808121</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acetylcholinesterase ; Aedes aegypti ; Antioxidants ; Artemia ; Artemia salina ; Biocompatibility ; Biological activity ; Ethanol ; Fabaceae ; Flavonoids ; Flowers ; Flowers &amp; plants ; Herbal medicine ; Isoflavones ; Leaves ; Medicine, Botanic ; Medicine, Herbal ; Natural products ; Phenolic compounds ; Phenols ; Phytochemicals ; Polyphenols ; Senna alata ; Senna cana ; Senna multijuga ; Senna pendula ; Senna reticulata ; Toxicity</subject><ispartof>Biochemistry research international, 2018-01, Vol.2018 (2018), p.1-10</ispartof><rights>Copyright © 2018 J. 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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Acetylcholinesterase
Aedes aegypti
Antioxidants
Artemia
Artemia salina
Biocompatibility
Biological activity
Ethanol
Fabaceae
Flavonoids
Flowers
Flowers & plants
Herbal medicine
Isoflavones
Leaves
Medicine, Botanic
Medicine, Herbal
Natural products
Phenolic compounds
Phenols
Phytochemicals
Polyphenols
Senna alata
Senna cana
Senna multijuga
Senna pendula
Senna reticulata
Toxicity
title Bioactivity and Toxicity of Senna cana and Senna pendula Extracts
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