The Combined Intervention of Aqua Exercise and Burdock Extract Synergistically Improved Arterial Stiffness: A Randomized, Double-Blind, Controlled Trial

Metabolic syndrome (MS), characterized by the presence of risk factors for various metabolic disorders, including impaired glucose tolerance, dyslipidemia, hypertension, and insulin resistance, has a high incidence in the Asian population. Among the various approaches used for improving MS, the comb...

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Published in:Metabolites 2022-10, Vol.12 (10), p.970
Main Authors: Ha, Min-Seong, Lee, Jae-Hoon, Jeong, Woo-Min, Kim, Hyun Ryun, Son, Woo Hyeon
Format: Article
Language:English
Subjects:
aqua exercise
Arctium
Atherosclerosis
Blood pressure
burdock extract
cardiovascular disease
Care and treatment
Cholesterol
Clinical trials
Diabetes
Diagnosis
Double-blind studies
Dyslipidemia
Evaluation
Exercise
Glucose
Glucose tolerance
Health aspects
Homeostasis
Hypertension
Insulin
Insulin resistance
Intervention
Metabolic disorders
Metabolic syndrome
Metabolic syndrome X
Nutrition research
Prostacyclin
Risk factors
Thromboxane A2
vascular endothelial function
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Summary:Metabolic syndrome (MS), characterized by the presence of risk factors for various metabolic disorders, including impaired glucose tolerance, dyslipidemia, hypertension, and insulin resistance, has a high incidence in the Asian population. Among the various approaches used for improving MS, the combination of exercise and nutrition is of increasing importance. In this randomized controlled trial, we evaluated the effects of combined aqua exercise and burdock extract intake on blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors in older women with MS. A total of 42 participants were randomly assigned into one of four groups (control, exercise, burdock, and exercise + burdock) and underwent a 16-week double-blinded intervention. Blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors were evaluated before and after the intervention. The 16-week intervention of aqua exercise decreased the levels of insulin, glucose, homeostasis model assessment of insulin resistance, and thromboxane A2, but increased the levels of the quantitative insulin sensitivity check index and prostaglandin I2. The combined burdock extract intake and aqua exercise intervention had an additional effect, improving the augmentation index, augmentation index at 75 beats per min, and pulse wave velocity. In conclusion, aqua exercise could improve insulin resistance and vascular regulation factors in older women with MS. Furthermore, combined treatment with burdock extract intake could improve arterial stiffness via a synergistic effect.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo12100970