Curcumin against Prostate Cancer: Current Evidence

Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2020-11, Vol.10 (11), p.1536
Main Authors: Termini, Deborah, Den Hartogh, Danja J, Jaglanian, Alina, Tsiani, Evangelia
Format: Article
Language:English
Subjects:
androgen-insensitive
androgen-sensitive
apoptosis
proliferation
prostate cancer
Review
survival
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Summary:Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key signaling pathways that control and promote homeostasis. Plant extracts and plant-derived compounds have historically been utilized as medicinal remedies in different cultures due to their anti-inflammatory, antioxidant, and antimicrobial properties. Many chemotherapeutic agents used in the treatment of cancer are derived from plants, and the scientific interest in discovering plant-derived chemicals with anticancer potential continues today. Curcumin, a turmeric-derived polyphenol, has been reported to possess antiproliferative and proapoptotic properties. In the present review, we summarize all the in vitro and in vivo studies examining the effects of curcumin in prostate cancer.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom10111536