Malignant Phyllodes Tumor of the Breast: A Practice Review

Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy. Objective: Our objective...

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Published in:Clinics and practice 2021-04, Vol.11 (2), p.205-215
Main Authors: Fede, Ângelo Bezerra de Souza, Pereira Souza, Ronaldo, Doi, Mauricio, De Brot, Marina, Aparecida Bueno de Toledo Osorio, Cynthia, Rocha Melo Gondim, Guilherme, Casali-da-Rocha, Jose Claudio, Jbili, Rima, Bitencourt, Almir Galvao Vieira, Alves de Souza, Juliana, Caparica Bitton, Rafael, Baroni Alves Makdissi, Fabiana, Moraes Sanches, Solange
Format: Article
Language:English
Subjects:
breast cancer
Cancer
fibroepithelial neoplasm
Hyperplasia
Kinases
Liposarcoma
malignant phyllodes tumor
Mutation
Pathogenesis
Review
Sarcoma
Tumors
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Summary:Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy. Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor. Conclusions: mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors.
ISSN:2039-7283
2039-7275
2039-7283
DOI:10.3390/clinpract11020030