Neoadjuvant radiotherapy for resectable retroperitoneal sarcoma: a meta-analysis

Neoadjuvant radiotherapy (NRT) for resectable retroperitoneal sarcoma (RPS) has been shown to be systematically feasible. Whether NRT has equivalent or better clinical effects compared to surgery alone for RPS patients remains controversial. We performed a systematic literature search of PubMed, Web...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2022-12, Vol.17 (1), p.215-11, Article 215
Main Authors: Li, Xiangji, Dong, Ruihan, Xiao, Mengmeng, Min, Li, Luo, Chenghua
Format: Article
Language:English
Subjects:
Care and treatment
Diagnosis
Humans
Meta-analysis
Methods
Multicenter Studies as Topic
Neoadjuvant radiotherapy
Neoadjuvant Therapy
Patient outcomes
Retroperitoneal Neoplasms - radiotherapy
Retroperitoneal Neoplasms - surgery
Retroperitoneal sarcoma
Sarcoma
Sarcoma - radiotherapy
Sarcoma - surgery
Soft Tissue Neoplasms
Soft tissue sarcoma
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Summary:Neoadjuvant radiotherapy (NRT) for resectable retroperitoneal sarcoma (RPS) has been shown to be systematically feasible. Whether NRT has equivalent or better clinical effects compared to surgery alone for RPS patients remains controversial. We performed a systematic literature search of PubMed, Web of Science, Embase, ASCO Abstracts, and Cochrane library databases for studies in humans with defined search terms. Articles were independently assessed by 2 reviewers, and only randomized controlled trials and cohort studies were included. The hazard ratios (HRs) of overall survival (OS), recurrence-free survival (RFS), and local recurrence (LR) were extracted from included studies. Heterogeneity among study-specific HRs was assessed by the Q statistic and I statistic. Overall HR was assessed by random-effects or fixed-effects models. Publication bias was tested by Begg's tests, and the quality of each study was assessed with the Newcastle Ottawa Scale. A total of 12 eligible studies with 7778 resectable RPS patients were finally included in this study. The pooled analysis revealed the distinct advantages of NRT as compared to surgery alone, including longer OS (HR = 0.81, P 
ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-022-02159-3