Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors

Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracell...

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Bibliographic Details
Published in:ACS omega 2020-03, Vol.5 (10), p.4937-4942
Main Authors: Eksteen, J. Johannes, Ausbacher, Dominik, Vasskog, Terje, Rekdal, Øystein, Svendsen, John S. M
Format: Article
Language:English
Subjects:
Clinical medical disciplines: 750
Klinisk medisinske fag: 750
Medical disciplines: 700
Medisinske Fag: 700
Oncology: 762
Onkologi: 762
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Summary:Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.9b00700