Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles-Efficacy in Cancer Treatment

The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production. In this study, folic acid (FA) was conjugated with a PLGA polymer followed by the formulation of drug-loaded NPs....

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Bibliographic Details
Published in:Pharmaceutics 2023-03, Vol.15 (3), p.1001
Main Authors: Parvathaneni, Vineela, Shukla, Snehal K, Gupta, Vivek
Format: Article
Language:English
Subjects:
3D spheroid studies
Acids
amodiaquine
Breast cancer
Cancer
Cancer therapies
Care and treatment
Cell cycle
Chemical properties
Chemotherapy
Drug delivery systems
Drugs
FDA approval
Folic acid
Health aspects
Ligands
Lipids
Lung cancer
Materials
Medical research
Nanoparticles
Polyethylene glycol
Polyvinyl alcohol
targeted delivery
Tumors
Vehicles
Vitamin B
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Summary:The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production. In this study, folic acid (FA) was conjugated with a PLGA polymer followed by the formulation of drug-loaded NPs. The results of the conjugation efficiency confirmed the conjugation of FA with PLGA. The developed folic acid-conjugated nanoparticles demonstrated uniform particle size distributions and had visible spherical shapes under transmission electron microscopy. The cellular uptake results suggested that FA modification could enhance the cellular internalization of nanoparticulate systems in non-small cell lung cancer, cervical, and breast cancer cell types. Furthermore, cytotoxicity studies showed the superior efficacy of FA-AQ NPs in different cancer cells such as MDAMB-231 and HeLA. FA-AQ NPs had better anti-tumor abilities demonstrated via 3D spheroid cell culture studies. Therefore, FA-AQ NPs could be a promising drug delivery system for cancer therapy.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15031001