Clinical implications of low estimated protein intake in patients with heart failure

• Published in: Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2022-06, Vol.13 (3), p.1762-1770
• Main Authors: Streng, Koen W., Hillege, Hans L., Maaten, Jozine M., Veldhuisen, Dirk J., Dickstein, Kenneth, Ng, Leong L., Samani, Nilesh J., Metra, Marco, Ponikowski, Piotr, Cleland, John G., Anker, Stefan D., Romaine, Simon P.R., Damman, Kevin, Meer, Peter, Lang, Chim C., Voors, Adriaan A.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Body Mass Index; Chronic obstructive pulmonary disease; Cohort Studies; Creatinine; Edema; Ejection fraction; Enzymes; Female; Heart failure; Heart Failure - metabolism; Hemoglobin; Humans; Laboratories; Male; Middle Aged; Mortality; Nitrogen; Obesity; Original; Patients; Peptides; Phosphatase; Proportional Hazards Models; Prospective Studies; Protein; Proteins; Urine; Variables
• ISSN: 2190-5991; 2190-6009
• DOI: 10.1002/jcsm.12973

Background A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are lacking. Methods We studied the prevalence, predictors, and clinical outcome of estimated protein intake in 2516 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) index cohort. Protein intake was calculated in spot urine samples using a validated formula [13.9 + 0.907 * body mass index (BMI) (kg/m2) + 0.0305 * urinary urea nitrogen level (mg/dL)]. Association with mortality was assessed using multivariable Cox regression models. All findings were validated in an independent cohort. Results We included 2282 HF patients (mean age 68 ± 12 years and 27% female). Lower estimated protein intake in HF patients was associated with a lower BMI, but with more signs of congestion. Mortality rate in the lowest quartile was 32%, compared with 18% in the highest quartile (P